Endocrine Abstracts

Aim: Following the general concern regarding the association between various diabetes treatments and cancer risk, the present study evaluated the cancer specific mortality in adult insulin-treated diabetes patients.Materials and methods: All diabetes patients residing in a major urban area, aged over 40 years and receiving insulin treatment were included at the moment of their first diabetes outpatient visit from 01/01/2001 to 12/31/2008. A total of 1136...

Introduction: Autoimmune thyroid disease affects 1% of the population and comprises several disorders, including Graves’ disease(GD). Local and serum cytokines are increased in patients with Graves disease, play a central role in co-ordinating immune reactions and have immunolgical and functional effects on thyroid cells.Aim: To investigate serum inflammatory and cytokines profile in untreated patients with Graves’ disease at diagnosis, when th...

Wolffian duct (WD) development is believed to be testosterone dependent. However, patients with complete androgen insensitivity syndrome (CAIS) and a causative mutation in the androgen receptor (AR) still develop WDs. Exceptions to this observation are those patients with severe N-terminal mutations. We investigated the role of the AR in WD development in these patients.AR expression in genital skin fibroblasts (GSF) from eleven patients with CAIS was studied by Western hy...

Intra-articular (IA) glucocorticoids (GCs) injections are effective in controlling joint inflammation but limited by short duration of action and off-target side effects. Gellan sheared hydrogels (SHs) area drug delivery vehicle, with unique thinning properties and enhanced release kinetics. We hypothesise that a combination of SHs and pre-receptor metabolism activated GCs provide slow-release drug delivery to target inflammation and minimise side-effects. We the release kinet...